CD147 promotes invasion and MMP-9 expression through MEK signaling and predicts poor prognosis in hypopharyngeal squamous cell carcinoma

Background Hypopharyngeal cancer is one of the most frequent head and neck cancers associated with a poor prognosis because recurrence metastases. Therefore, there need to improve prognosis, which requires identification prognostic factors elucidation mechanisms involved in tumor progression. Accumulated evidence has demonstrated that cluster differentiation 147 (CD147) strongly expressed malignant tumors, including squamous cell carcinoma (HNSCC), contributes Objectives To investigate CD147-induced signaling pathways HNSCC cells evaluate progression mediated by CD147, association between CD147 expression tumors survival rate hypopharyngeal patients. Material methods determine downstream HNSCC, levels phosphorylated AKT1, MEK1, p38 MAPK, STAT3, NF-?B were evaluated using enzyme-linked immunosorbent assay (ELISA) FaDu, line, exposed cyclophilin A, ligand. Results We found patients expressing showed five-year overall (OS) 11.1% compared those without (43.0%) (p = 0.02). confirmed MEK matrix metalloproteinase-9 (MMP-9), as well invasion ability, enhanced cells. In addition, this increased infiltration enhancement MMP-9 induced abolished inhibitor. Conclusions These results suggest can be predictor MEK-mediated intracellular pathway plays crucial role carcinoma.